Deep Clustering Activation Maps for Emphysema Subtyping

Weiyi Xie · March 1, 2021

Table of Contents

Motivation
Method
Results
Cite

Motivation

This study proposes a deep learning-based clustering framework to find emphysema subtypes in a data-driven fashion. The existing approaches in this field are k-means based clustering methods that use hand-craft features, meaning that they are hardly reproducible and sensitive to changes. Furthermore, we address the issue of the lack of model interpretability in deep learning clustering methods by visualizing dense class activation maps as the regions reflect the clustering decisions.

Method

The key innovation of this method is to use a deep clustering framework, which alternates between learning the clustering assignment and feature extraction by freezing parts of the network depending on the learning objective. Meanwhile, we use a segmentation network as the backbone to generate clustering activation maps in high-resolution, which improves the model interpretability. The following figure shows how to alternate between clustering and feature extraction in the deep clustering framework.

Qries

please refer to the published paper for more details.

Results

  • We evaluated on 500 scans. The proposed model reached 43% unsupervised clustering accuracy, outperforming the baseline at 41%,. In terms of internal cluster measurement, we achieved 0.55 in DavidBouldin index and 0.54 in silhouette coefficient, showing a substantial improvement over the baseline.
Qries

Cite

If you find this algorithm useful in your research, please consider citing:

@article{xie2021dense,
    author={Xie, Weiyi and Jacobs, Colin and van Ginneken, Bram},
    title={Deep Clustering Activation Maps for Emphysema Subtyping},
    journal={arXiv preprint arXiv:2106.01351},
    year = {2021},  
}

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